About Gene List

PF3D7_1466200 (HDP1)

Genome location: Pf3D7_14_v3:2,694,514..2,706,476(-)

Genome classification: Core

Function and Localization

Product Description: homeodomain-like protein HDP1

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus
Function GO:0003677 DNA binding
Process GO:0006355 regulation of transcription, DNA-templated

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring possibly expressed 0.19 0.91
Trophozoite expressed 0.42 0.77
Schizont expressed 0.37 0.78
Gametocyte expressed 1.95 0.23

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1466200

Resistome Missense Mutations: N293K

Resistome Compounds with Missense Mutations: TCMDC-125334

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.316 | #Insertions: 10

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1329600)

Modification: Disrupted | RMgm-4282

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_196110

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 26 170 78 208
disruptive 167 477 227 490
missense 101 380 200 413

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 44 313 108 234
disruptive 254 862 331 653
missense 161 699 276 463

PlasmoDB Total SNPs: 710

Non-coding: 192 | Synonymous: 331 | Nonsynonymous: 186 | Stop Codon: 1

Protein Information

Protein Length: 3078 | Molecular Weight (kDa): 355.935

UniProt ID(s): Q8IKH4, Q9GVA8

PDB ID(s): None

Isoelectric Point: 6.21

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
35087229 The transcriptional regulator HDP1 controls expansion of the inner membranecomplex during early sexual differentiation of malaria parasites. Campelo Morillo RA, Tong X, ..., Kafsack BFC 10.1038/s41564-021-01045-0
35136229 Publisher Correction: The transcriptional regulator HDP1 controls expansion ofthe inner membrane complex during early sexual differentiation of malariaparasites Campelo Morillo RA, Tong X, ..., Kafsack BFC 10.1038/s41564-022-01082-3
35871979 A transcription factor helps Plasmodium falciparum gametocytogenesis take shape McLean KJ, Niles JC 10.1016/j.pt.2022.07.004