Product Description: enkurin domain-containing protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0005516 | calmodulin binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.08 | 0.96 |
| Trophozoite | not expressed | 0.04 | 0.98 |
| Schizont | not expressed | 0.01 | 0.99 |
| Gametocyte | expressed | 0.69 | 0.73 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1466600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.797 | #Insertions: 4
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKH1
"Best" AlphaFill ligand hit: CTP (cytidine-5'-triphosphate, Local RMSD=0.08) with 7ECD (Global RMSD=29.49)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103778
Most Similar Human Ortholog: L7N489
TM-align score: 0.39 | RMSD: 4.76
Seq Identity: 0.13 | Length: 90 / 280
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000151023 | enkurin, TRPC channel interacting protein |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 26 | 18 | 24 |
| disruptive | 6 | 35 | 19 | 50 |
| missense | 6 | 35 | 19 | 44 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 52 | 14 | 21 |
| disruptive | 16 | 79 | 39 | 124 |
| missense | 15 | 67 | 32 | 82 |
PlasmoDB Total SNPs: 20
Non-coding: 0 | Synonymous: 11 | Nonsynonymous: 9 | Stop Codon: 0
Protein Length: 280 | Molecular Weight (kDa): 33.002
UniProt ID(s): Q8IKH1
PDB ID(s): None
Isoelectric Point: 9.86
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR026150 | Enkurin |
| InterPro | IPR027012 | Enkurin domain |
| PFam | PF13864 | Enkurin domain |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |