Genome location: Pf3D7_14_v3:2,728,891..2,730,944(+)
Genome classification: Core
Product Description: 60S ribosome subunit biogenesis protein NIP7, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005730 | nucleolus |
| Component | GO:0030687 | preribosome, large subunit precursor |
| Process | GO:0042273 | ribosomal large subunit biogenesis |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.16 | 0.92 |
| Trophozoite | possibly expressed | 0.14 | 0.92 |
| Schizont | not expressed | 0.02 | 0.99 |
| Gametocyte | not expressed | 0.08 | 0.95 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1466700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.346 | MFS: -3.558 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKH0
"Best" AlphaFill ligand hit: DPF (diethyl hydrogen phosphate, Local RMSD=2.82) with 3UR5 (Global RMSD=15.37)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102224
Most Similar Human Ortholog: Q9Y221
TM-align score: 0.96 | RMSD: 1.03
Seq Identity: 0.40 | Length: 179 / 179
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000132603 | nucleolar pre-rRNA processing protein NIP7 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 13 | 8 | 15 |
| disruptive | 3 | 9 | 4 | 24 |
| missense | 3 | 9 | 4 | 19 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 27 | 8 | 11 |
| disruptive | 5 | 26 | 15 | 41 |
| missense | 4 | 23 | 14 | 31 |
PlasmoDB Total SNPs: 127
Non-coding: 117 | Synonymous: 8 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 179 | Molecular Weight (kDa): 20.411
UniProt ID(s): Q8IKH0
PDB ID(s): None
Isoelectric Point: 9.67
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002478 | PUA domain |
| InterPro | IPR005155 | UPF0113, PUA domain |
| InterPro | IPR015947 | PUA-like superfamily |
| InterPro | IPR016686 | Ribosome biogenesis factor, NIP7 |
| InterPro | IPR040598 | UPF0113, pre-PUA domain |
| PFam | PF03657 | UPF0113, PUA domain |
| PFam | PF17833 | UPF0113, pre-PUA domain |
| Superfamily | SSF88697 | PUA-like superfamily |
| Superfamily | SSF88802 |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 22380876 | Heterologous expression of the yeast arsenite efflux system ACR3 improvesArabidopsis thaliana tolerance to arsenic stress | Ali W, Isner JC, ..., Maathuis FJM | 10.1111/j.1469-8137.2012.04092.x |
| 22735702 | Hierarchical recruitment into nascent ribosomes of assembly factors required for27SB pre-rRNA processing in Saccharomyces cerevisiae | Talkish J, Zhang J, ..., Woolford JL Jr | 10.1093/nar/gks609 |
| 37811893 | Yeast ribosome biogenesis factors Puf6 and Nog2 and ribosomal proteins uL2 andeL43 act in concert to facilitate the release of nascent large ribosomal subunitsfrom the nucleolus | LaPeruta AJ, Hedayati S, ..., Woolford JL | 10.1093/nar/gkad794 |