About Gene List

PF3D7_1466800

Genome location: Pf3D7_14_v3:2,731,557..2,735,622(+)

Genome classification: Core

Function and Localization

Product Description: NOC3 domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus
Function GO:0003682 chromatin binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.35 0.83
Trophozoite expressed 0.35 0.80
Schizont not expressed 0.07 0.96
Gametocyte expressed 1.85 0.29

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1466800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.134 | MFS: -2.879 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKG9

"Best" AlphaFill ligand hit: ADN (adenosine, Local RMSD=10.25) with 6SHU (Global RMSD=16.94)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532825

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 16 41 26 74
disruptive 5 45 22 75
missense 5 45 22 69

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 18 90 42 81
disruptive 10 86 44 152
missense 10 79 41 121

PlasmoDB Total SNPs: 124

Non-coding: 86 | Synonymous: 26 | Nonsynonymous: 12 | Stop Codon: 0

Protein Information

Protein Length: 902 | Molecular Weight (kDa): 105.448

UniProt ID(s): Q8IKG9

PDB ID(s): None

Isoelectric Point: 8.7

Protein Domain Annotations:

Source Family ID Description
InterPro IPR011501 Nucleolar complex-associated protein 3, N-terminal
InterPro IPR016903 Nucleolar complex-associated protein 3
PFam PF07540 Nucleolar complex-associated protein 3, N-terminal
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
30379851 Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. Briquet S, Ourimi A, ..., Vaquero C 10.1371/journal.pone.0205596