About Gene List

PF3D7_1466900

Genome location: Pf3D7_14_v3:2,736,036..2,741,770(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.68 0.69
Trophozoite possibly expressed 0.84 0.55
Schizont expressed 0.54 0.67
Gametocyte not expressed 0.57 0.68

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1466900

Resistome Missense Mutations: Y67F

Resistome Compounds with Missense Mutations: AN13762

Resistome # Samples with Disruptive Mutations: 6 (2 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.123 | MFS: -2.972 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKG8

"Best" AlphaFill ligand hit: CLQ (n4-(7-chloro-quinolin-4-yl)-n1,n1-diethyl-pentane-1,4-diamine, Local RMSD=0.13) with 7DI7 (Global RMSD=25.35)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533089

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 10 75 42 101
disruptive 72 234 141 299
missense 51 198 130 264

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 25 130 64 107
disruptive 114 484 202 378
missense 84 402 167 288

PlasmoDB Total SNPs: 326

Non-coding: 128 | Synonymous: 81 | Nonsynonymous: 117 | Stop Codon: 0

Protein Information

Protein Length: 1416 | Molecular Weight (kDa): 169.342

UniProt ID(s): Q8IKG8

PDB ID(s): None

Isoelectric Point: 4.47

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108