PF3D7_1467000

Genome location: Pf3D7_14_v3:2,742,387..2,745,257(+)

Genome classification: Core

Function and Localization

Product Description: magnesium transporter, putative

SignalP Peptide: N/A

# Transmembrane Domains: 8

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0016020	membrane
Function	GO:0015095	magnesium ion transmembrane transporter activity
Process	GO:0015693	magnesium ion transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.05	0.98
Trophozoite	possibly expressed	0.03	0.98
Schizont	not expressed	0.04	0.98
Gametocyte	expressed	0.30	0.83

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1467000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.983 | MFS: -2.507 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A2U1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_105090

Most Similar Human Ortholog: Q69YG0

TM-align score: 0.61 | RMSD: 3.21

Seq Identity: 0.11 | Length: 127 / 901

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000169964	transmembrane protein 42
ENSG00000280516	transmembrane protein 42

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	12	50	41	70
disruptive	19	129	83	167
missense	18	126	81	150

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	25	103	49	63
disruptive	46	299	133	252
missense	32	275	114	197

PlasmoDB Total SNPs: 100

Non-coding: 10 | Synonymous: 62 | Nonsynonymous: 27 | Stop Codon: 1

Protein Information

Protein Length: 901 | Molecular Weight (kDa): 106.994

UniProt ID(s): A0A144A2U1

PDB ID(s): None

Isoelectric Point: 10.24

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR008521	Magnesium transporter NIPA
PFam	PF05653	Magnesium transporter NIPA
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
11152613	Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes.	Krogh A, Larsson B, von Heijne G, Sonnhammer EL	10.1006/jmbi.2000.4315
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097