Genome location: Pf3D7_14_v3:2,748,205..2,750,150(+)
Genome classification: Core
Product Description: WD repeat-containing protein 79, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.38 | 0.82 |
| Trophozoite | expressed | 0.25 | 0.86 |
| Schizont | possibly expressed | 0.04 | 0.97 |
| Gametocyte | not expressed | 0.20 | 0.88 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1467200
Resistome Missense Mutations: F255Y
Resistome Compounds with Missense Mutations: MMV665794
Resistome # Samples with Disruptive Mutations: 3 (3 missense, 3 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.968 | MFS: -2.557 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_1330500)
Modification: Other | RMgm-434
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKG5
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102801
Most Similar Human Ortholog: K7EJ50
TM-align score: 0.72 | RMSD: 1.94
Seq Identity: 0.36 | Length: 45 / 579
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000141499 | WD repeat containing antisense to TP53 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 20 | 19 | 44 |
| disruptive | 22 | 101 | 45 | 110 |
| missense | 14 | 81 | 39 | 95 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 63 | 30 | 33 |
| disruptive | 43 | 172 | 68 | 158 |
| missense | 28 | 144 | 56 | 121 |
PlasmoDB Total SNPs: 61
Non-coding: 14 | Synonymous: 31 | Nonsynonymous: 16 | Stop Codon: 0
Protein Length: 579 | Molecular Weight (kDa): 69.046
UniProt ID(s): Q8IKG5
PDB ID(s): None
Isoelectric Point: 4.87
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001680 | WD40 repeat |
| InterPro | IPR036322 | WD40-repeat-containing domain superfamily |
| PFam | N/A | N/A |
| Superfamily | SSF50978 | WD40-repeat-containing domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 31147702 | Pseudouridines on Trypanosoma brucei spliceosomal small nuclear RNAs and theirimplication for RNA and protein interactions | Rajan KS, Doniger T, ..., Michaeli S | 10.1093/nar/gkz477 |