Genome location: Pf3D7_14_v3:2,752,541..2,754,593(-)
Genome classification: Core
Product Description: 50S ribosomal protein L22, apicoplast, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Component | GO:0015934 | large ribosomal subunit |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0042255 | ribosome assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.12 | 0.94 |
| Trophozoite | not expressed | 0.54 | 0.69 |
| Schizont | possibly expressed | 0.28 | 0.82 |
| Gametocyte | not expressed | 0.32 | 0.81 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1467400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.125 | MFS: -2.984 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKG3
"Best" AlphaFill ligand hit: MIV (mycinamicin iv, Local RMSD=0.04) with 7A18 (Global RMSD=1.90)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101227
Most Similar Human Ortholog: Q9NWU5
TM-align score: 0.52 | RMSD: 2.74
Seq Identity: 0.20 | Length: 121 / 294
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000082515 | mitochondrial ribosomal protein L22 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 11 | 11 | 11 |
| disruptive | 5 | 19 | 10 | 32 |
| missense | 5 | 19 | 10 | 30 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 28 | 9 | 22 |
| disruptive | 11 | 31 | 21 | 45 |
| missense | 10 | 26 | 18 | 36 |
PlasmoDB Total SNPs: 90
Non-coding: 64 | Synonymous: 16 | Nonsynonymous: 10 | Stop Codon: 0
Protein Length: 294 | Molecular Weight (kDa): 35.196
UniProt ID(s): Q8IKG3
PDB ID(s): None
Isoelectric Point: 10.46
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001063 | Ribosomal protein L22/L17 |
| InterPro | IPR005727 | Ribosomal protein L22, bacterial/chloroplast-type |
| InterPro | IPR018260 | Ribosomal protein L22/L17, conserved site |
| InterPro | IPR036394 | Ribosomal protein L22/L17 superfamily |
| PFam | PF00237 | Ribosomal protein L22/L17 |
| Superfamily | SSF54843 | Ribosomal protein L22/L17 superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |