PF3D7_1467500

Genome location: Pf3D7_14_v3:2,754,609..2,757,177(+)

Genome classification: Core

Function and Localization

Product Description: DNA/RNA-binding protein KIN17, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus
Function	GO:0003690	double-stranded DNA binding
Process	GO:0006260	DNA replication
Process	GO:0006974	cellular response to DNA damage stimulus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.35	0.83
Trophozoite	possibly expressed	0.74	0.59
Schizont	not expressed	0.26	0.83
Gametocyte	not expressed	0.30	0.83

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1467500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.227 | MFS: -2.682 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKG2

"Best" AlphaFill ligand hit: GSH (glutathione, Local RMSD=25.91) with 6SRB (Global RMSD=25.02)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102520

Most Similar Human Ortholog: S4R357

TM-align score: 0.83 | RMSD: 1.52

Seq Identity: 0.32 | Length: 98 / 442

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000151657	Kin17 DNA and RNA binding protein

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	28	10	26
disruptive	1	31	40	65
missense	1	30	40	64

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	44	25	28
disruptive	11	78	58	85
missense	6	75	58	62

PlasmoDB Total SNPs: 124

Non-coding: 83 | Synonymous: 32 | Nonsynonymous: 9 | Stop Codon: 0

Protein Information

Protein Length: 442 | Molecular Weight (kDa): 52.461

UniProt ID(s): Q8IKG2

PDB ID(s): None

Isoelectric Point: 9.55

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR013087	Zinc finger C2H2-type
InterPro	IPR019447	DNA/RNA-binding protein Kin17, conserved domain
InterPro	IPR036236	Zinc finger C2H2 superfamily
InterPro	IPR037321	KIN17-like protein
InterPro	IPR041330	KN17, SH3-like C-terminal domain
PFam	PF10357	DNA/RNA-binding protein Kin17, conserved domain
PFam	PF18131	KN17, SH3-like C-terminal domain
Superfamily	SSF57667	Zinc finger C2H2 superfamily