About Gene List

PF3D7_1467600

Genome location: Pf3D7_14_v3:2,757,022..2,765,652(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.17 0.93
Trophozoite expressed 0.24 0.89
Schizont expressed 0.13 0.93
Gametocyte expressed 1.30 0.42

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1467600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 1.158 | #Insertions: 7

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0832100)

  • Relative Growth Rate: 0.93 ± 0.21
  • Confidence: 4.49

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1330900)

Modification: Disrupted | RMgm-3552

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A2Q6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_112007

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 14 73 41 92
disruptive 85 333 163 362
missense 54 260 134 292

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 26 122 62 101
disruptive 164 551 240 403
missense 104 438 190 307

PlasmoDB Total SNPs: 903

Non-coding: 213 | Synonymous: 393 | Nonsynonymous: 295 | Stop Codon: 2

Protein Information

Protein Length: 2104 | Molecular Weight (kDa): 236.928

UniProt ID(s): A0A144A2Q6

PDB ID(s): None

Isoelectric Point: 9.42

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108