PF3D7_1467700

Genome location: Pf3D7_14_v3:2,765,528..2,766,792(+)

Genome classification: Core

Function and Localization

Product Description: COX domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.03	0.98
Trophozoite	expressed	0.12	0.92
Schizont	expressed	0.03	0.98
Gametocyte	expressed	0.20	0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1467700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.348 | MFS: -3.608 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKG0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_122964

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	3	8	4
disruptive	2	10	4	13
missense	1	10	4	13

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	12	5	1
disruptive	2	22	9	33
missense	1	21	8	21

PlasmoDB Total SNPs: 51

Non-coding: 44 | Synonymous: 4 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 82 | Molecular Weight (kDa): 9.717

UniProt ID(s): Q8IKG0

PDB ID(s): None

Isoelectric Point: 8.1

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR003213	Cytochrome c oxidase, subunit VIb
PFam	PF02297	Cytochrome c oxidase, subunit VIb
Superfamily	N/A	N/A