PF3D7_1467800

Genome location: Pf3D7_14_v3:2,767,400..2,768,020(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	not expressed	0.02	0.98
Schizont	not expressed	0.01	0.99
Gametocyte	not expressed	0.04	0.98

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1467800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.14 | MFS: -3.131 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1331100)

Modification: Disrupted | RMgm-498

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKF9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215382

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	8	2	7
disruptive	1	3	4	10
missense	1	3	4	10

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	13	5	6
disruptive	1	13	6	18
missense	1	12	4	15

PlasmoDB Total SNPs: 26

Non-coding: 18 | Synonymous: 7 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 90 | Molecular Weight (kDa): 10.683

UniProt ID(s): Q8IKF9

PDB ID(s): None

Isoelectric Point: 8.24

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A