PF3D7_1467900

Genome location: Pf3D7_14_v3:2,770,650..2,777,339(+)

Genome classification: Core

Function and Localization

Product Description: rab GTPase activator, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1467900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.988 | MFS: -2.723 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKF8

"Best" AlphaFill ligand hit: AMP (adenosine monophosphate, Local RMSD=1.67) with 6JWQ (Global RMSD=33.94)

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104315

Most Similar Human Ortholog: A0A0D9SFR5

TM-align score: 0.75 | RMSD: 3.72

Seq Identity: 0.17 | Length: 303 / 1656

All Human Orthologs (OrthoMCL):

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

Any inclusion in genotype call

PlasmoDB Total SNPs: 224

Non-coding: 118 | Synonymous: 62 | Nonsynonymous: 42 | Stop Codon: 2

Protein Information

Protein Length: 1656 | Molecular Weight (kDa): 196.056

UniProt ID(s): Q8IKF8

PDB ID(s): None

Isoelectric Point: 6.91

Protein Domain Annotations: