PF3D7_1468000

Genome location: Pf3D7_14_v3:2,777,632..2,785,114(+)

Genome classification: Core

Function and Localization

Product Description: WD repeat-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.05	0.98
Trophozoite	not expressed	0.13	0.92
Schizont	not expressed	0.14	0.92
Gametocyte	not expressed	0.62	0.74

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1468000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.845 | #Insertions: 6

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKF7

"Best" AlphaFill ligand hit: LFA (lipid fragment, Local RMSD=0.19) with 7AKW (Global RMSD=20.45)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103568

Most Similar Human Ortholog: C9K0A4

TM-align score: 0.42 | RMSD: 3.43

Seq Identity: 0.00 | Length: 58 / 1966

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000206530	cilia and flagella associated protein 44

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	29	117	59	134
disruptive	44	220	151	374
missense	41	210	143	350

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	45	223	78	143
disruptive	101	565	227	511
missense	71	494	203	397

PlasmoDB Total SNPs: 321

Non-coding: 187 | Synonymous: 78 | Nonsynonymous: 54 | Stop Codon: 2

Protein Information

Protein Length: 1966 | Molecular Weight (kDa): 238.302

UniProt ID(s): Q8IKF7

PDB ID(s): None

Isoelectric Point: 9.15

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR036322	WD40-repeat-containing domain superfamily
PFam	N/A	N/A
Superfamily	SSF50978	WD40-repeat-containing domain superfamily