Genome location: Pf3D7_14_v3:2,785,386..2,797,934(-)
Genome classification: Core
Product Description: MORC family protein
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Process | GO:0051726 | regulation of cell cycle |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.57 | 0.39 |
| Trophozoite | expressed | 1.93 | 0.22 |
| Schizont | expressed | 2.20 | 0.23 |
| Gametocyte | expressed | 1.41 | 0.34 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1468100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.179 | MFS: -2.717 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1331400)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKF6
"Best" AlphaFill ligand hit: ANP (phosphoaminophosphonic acid-adenylate ester, Local RMSD=2.17) with 7K7T (Global RMSD=4.03)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 29 | 136 | 87 | 191 |
| disruptive | 131 | 367 | 160 | 433 |
| missense | 62 | 255 | 131 | 319 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 51 | 282 | 121 | 193 |
| disruptive | 230 | 634 | 339 | 626 |
| missense | 116 | 454 | 261 | 437 |
PlasmoDB Total SNPs: 569
Non-coding: 317 | Synonymous: 127 | Nonsynonymous: 125 | Stop Codon: 0
Protein Length: 2558 | Molecular Weight (kDa): 295.83
UniProt ID(s): Q8IKF6
PDB ID(s): None
Isoelectric Point: 4.99
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR015915 | Kelch-type beta propeller |
| InterPro | IPR036890 | Histidine kinase/HSP90-like ATPase superfamily |
| PFam | PF13418 | N/A |
| Superfamily | SSF117281 | Kelch-type beta propeller |
| Superfamily | SSF55874 | Histidine kinase/HSP90-like ATPase superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33479315 | A nuclear protein, PfMORC confers melatonin dependent synchrony of the humanmalaria parasite P. falciparum in the asexual stage. | Singh MK, Tessarin-Almeida G, ..., Garcia CRS | 10.1038/s41598-021-81235-2 |
| 37892209 | Novel Insights into the Role of Chromatin Remodeler MORC2 in Cancer | Chutani N, Ragula S, Syed K, Pakala SB | 10.3390/biom13101527 |
| 37692502 | Oncogenic MORC2 in cancer development and beyond | Zhang S, Guo A, ..., Wang G | 10.1016/j.gendis.2023.05.010 |
| 36932196 | MORC4 plays a tumor-promoting role in colorectal cancer via regulating PCGF1/CDKN1A axis in vitro and in vivo | Liang Y, Wu D, ..., Yin H | 10.1038/s41417-023-00605-2 |
| 36793866 | Dynamic SUMOylation of MORC2 orchestrates chromatin remodelling and DNA repair inresponse to DNA damage and drives chemoresistance in breast cancer | Zhang FL, Yang SY, ..., Li DQ | 10.7150/thno.79688 |
| 36711883 | In vitro production of cat-restricted Toxoplasma pre-sexual stages by epigenetic reprogramming | Antunes AV, Shahinas M, ..., Hakimi MA | 10.1101/2023.01.16.524187 |
| 38093015 | In vitro production of cat-restricted Toxoplasma pre-sexual stages | Antunes AV, Shahinas M, ..., Hakimi MA | 10.1038/s41586-023-06821-y |
| 37750704 | AP2XII-1 is a negative regulator of merogony and presexual commitment inToxoplasma gondii | Fan F, Xue L, ..., Shen B | 10.1128/mbio.01785-23 |
| 37101218 | MORC proteins regulate transcription factor binding by mediating chromatincompaction in active chromatin regions | Zhong Z, Xue Y, ..., Jacobsen SE | 10.1186/s13059-023-02939-4 |
| 36786611 | Toxoplasma gondii AP2XII-2 Contributes to Transcriptional Repression for SexualCommitment | Srivastava S, Holmes MJ, White MW, Sullivan WJ Jr | 10.1128/msphere.00606-22 |
| 35522895 | HSP90 N-terminal inhibitors target oncoprotein MORC2 for autophagic degradationand suppress MORC2-driven breast cancer progression | Yang F, Sun R, ..., Li DQ | 10.1002/ctm2.825 |
| 37745554 | PfMORC protein regulates chromatin accessibility and transcriptional repressionin the human malaria parasite, P. falciparum | Chahine Z, Gupta M, ..., Le Roch KG | 10.1101/2023.09.11.557253 |
| 34974534 | O-GlcNAcylation of MORC2 at threonine 556 by OGT couples TGF-beta signaling to breast cancer progression | Liu YY, Liu HY, ..., Li DQ | 10.1038/s41418-021-00901-0 |