Genome location: Pf3D7_14_v3:2,800,972..2,803,435(+)
Genome classification: Core
Product Description: telomere length and silencing protein 1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Component | GO:0005681 | spliceosomal complex |
| Process | GO:0048024 | regulation of mRNA splicing, via spliceosome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.48 | 0.78 |
| Trophozoite | expressed | 0.58 | 0.69 |
| Schizont | expressed | 0.70 | 0.64 |
| Gametocyte | not expressed | 0.39 | 0.78 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1468200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.444 | MFS: -1.455 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKF5
"Best" AlphaFill ligand hit: HEM (heme, Local RMSD=1.04) with 8SQO (Global RMSD=27.65)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103943
Most Similar Human Ortholog: Q9NZ63
TM-align score: 0.22 | RMSD: 5.20
Seq Identity: 0.04 | Length: 79 / 226
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000136819 | chromosome 9 open reading frame 78 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 14 | 4 | 14 |
| disruptive | 10 | 43 | 35 | 44 |
| missense | 10 | 32 | 28 | 35 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 26 | 5 | 17 |
| disruptive | 19 | 99 | 32 | 66 |
| missense | 12 | 78 | 24 | 47 |
PlasmoDB Total SNPs: 116
Non-coding: 97 | Synonymous: 9 | Nonsynonymous: 10 | Stop Codon: 0
Protein Length: 226 | Molecular Weight (kDa): 27.098
UniProt ID(s): Q8IKF5
PDB ID(s): None
Isoelectric Point: 8.88
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR010756 | Telomere length and silencing protein 1 |
| PFam | PF07052 | Telomere length and silencing protein 1 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |