PF3D7_1468300 (LRR14.1)

Genome location: Pf3D7_14_v3:2,803,593..2,804,613(+)

Genome classification: Core

Function and Localization

Product Description: leucine-rich repeat protein

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0008171	O-methyltransferase activity

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	not expressed	0.01	1.00
Schizont	not expressed	0.02	0.98
Gametocyte	not expressed	0.11	0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1468300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.272 | MFS: -3.425 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKF4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_106382

Most Similar Human Ortholog: Q96E66

TM-align score: 0.71 | RMSD: 2.86

Seq Identity: 0.24 | Length: 155 / 249

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000184154	leucine rich transmembrane and O-methyltransferase domain containing

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	9	7	19
disruptive	3	21	16	45
missense	3	21	16	43

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	25	10	26
disruptive	4	58	33	71
missense	4	51	26	56

PlasmoDB Total SNPs: 37

Non-coding: 26 | Synonymous: 5 | Nonsynonymous: 5 | Stop Codon: 1

Protein Information

Protein Length: 249 | Molecular Weight (kDa): 29.676

UniProt ID(s): A5JTT9, Q8IKF4

PDB ID(s): None

Isoelectric Point: 7.35

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	PF14580	N/A
Superfamily	SSF52058	N/A