PF3D7_1468400 (CZIF1)

Genome location: Pf3D7_14_v3:2,809,460..2,812,520(+)

Genome classification: Core

Function and Localization

Product Description: C3H1-type zinc finger protein CZIF1

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005829	cytosol
Component	GO:0016020	membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.16	0.92
Trophozoite	not expressed	0.09	0.95
Schizont	possibly expressed	1.37	0.52
Gametocyte	not expressed	0.25	0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1468400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.943 | MFS: -2.623 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A3J8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_148954

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	48	31	76
disruptive	36	158	97	180
missense	26	142	93	147

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	110	42	69
disruptive	71	348	156	296
missense	54	293	122	189

PlasmoDB Total SNPs: 121

Non-coding: 13 | Synonymous: 43 | Nonsynonymous: 65 | Stop Codon: 0

Protein Information

Protein Length: 862 | Molecular Weight (kDa): 99.706

UniProt ID(s): A0A144A3J8, Q867W4, Q868T2

PDB ID(s): None

Isoelectric Point: 5.11

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000571	Zinc finger, CCCH-type
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104