About Gene List

PF3D7_1468500 (DER1-1)

Genome location: Pf3D7_14_v3:2,812,237..2,814,434(-)

Genome classification: Core

Function and Localization

Product Description: derlin-1

SignalP Peptide: N/A

# Transmembrane Domains: 5

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex
Component GO:0005783 endoplasmic reticulum
Component GO:0005789 endoplasmic reticulum membrane
Component GO:0030176 integral component of endoplasmic reticulum membrane
Function GO:0051787 misfolded protein binding
Function GO:1990381 ubiquitin-specific protease binding
Process GO:0030968 endoplasmic reticulum unfolded protein response
Process GO:0030970 retrograde protein transport, ER to cytosol
Process GO:0030433 ubiquitin-dependent ERAD pathway

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed nd nd
Trophozoite possibly expressed nd nd
Schizont possibly expressed nd nd
Gametocyte not expressed nd nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1468500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.119 | MFS: -3.267 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1331800)

  • Relative Growth Rate: 0.79 ± 0.11
  • Confidence: 5.88

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1331800)

Modification: Disrupted | RMgm-3554

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKF2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101672

Most Similar Human Ortholog: Q9GZP9

TM-align score: 0.92 | RMSD: 1.62

Seq Identity: 0.32 | Length: 211 / 214

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000072849 derlin 2

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 14 10 21
disruptive 2 2 2 6
missense 2 2 2 5

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 9 29 10 16
disruptive 2 16 6 38
missense 2 9 5 31

PlasmoDB Total SNPs: 171

Non-coding: 159 | Synonymous: 11 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 214 | Molecular Weight (kDa): 25.102

UniProt ID(s): C7SP48, Q8IKF2

PDB ID(s): None

Isoelectric Point: 7.61

Protein Domain Annotations:

Source Family ID Description
InterPro IPR007599 Derlin
PFam PF04511 Derlin
Superfamily SSF144091 N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
19502583 An unusual ERAD-like complex is targeted to the apicoplast of Plasmodiumfalciparum Spork S, Hiss JA, ..., Przyborski JM 10.1128/EC.00083-09