About Gene List

PF3D7_1468600

Genome location: Pf3D7_14_v3:2,816,100..2,822,286(+)

Genome classification: Core

Function and Localization

Product Description: aminophospholipid transporter, putative

SignalP Peptide: N/A

# Transmembrane Domains: 10

EC Numbers: 3.6.3.1 (Transferred entry: 7.6.2.1)

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0016020 membrane
Component GO:0005886 plasma membrane
Function GO:0140326 ATPase-coupled intramembrane lipid transporter activity
Process GO:0045332 phospholipid translocation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.03 0.99
Trophozoite not expressed 0.15 0.92
Schizont not expressed 0.11 0.93
Gametocyte not expressed 0.63 0.70

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1468600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.749 | #Insertions: 9

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKF1

"Best" AlphaFill ligand hit: ADN (adenosine, Local RMSD=11.23) with 3QWU (Global RMSD=15.58)

BRENDA EC Inhibitors:

EC # Name EC Inhibitors
3.6.3.1 phospholipid-translocating ATPase No BRENDA inhibitors

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533073

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 20 105 77 156
disruptive 94 412 225 478
missense 57 347 205 427

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 40 233 98 164
disruptive 176 817 345 645
missense 102 695 297 481

PlasmoDB Total SNPs: 251

Non-coding: 49 | Synonymous: 88 | Nonsynonymous: 113 | Stop Codon: 1

Protein Information

Protein Length: 2008 | Molecular Weight (kDa): 240.462

UniProt ID(s): Q8IKF1

PDB ID(s): None

Isoelectric Point: 9.54

Protein Domain Annotations:

Source Family ID Description
InterPro IPR006539 P-type ATPase, subfamily IV
InterPro IPR036412 HAD-like superfamily
PFam N/A N/A
Superfamily SSF56784 HAD-like superfamily

Associated Publications

PMID Title Authors DOI/Link
11152613 Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. Krogh A, Larsson B, von Heijne G, Sonnhammer EL 10.1006/jmbi.2000.4315
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097