PF3D7_1468900

Genome location: Pf3D7_14_v3:2,831,386..2,834,620(-)

Genome classification: Core

Function and Localization

Product Description: zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0016604	nuclear body
Component	GO:0005634	nucleus
Process	GO:0031053	primary miRNA processing

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.27	0.87
Trophozoite	possibly expressed	0.52	0.70
Schizont	not expressed	0.06	0.96
Gametocyte	not expressed	0.41	0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1468900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.695 | MFS: -3.13 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKE8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533723

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	37	24	50
disruptive	13	106	51	156
missense	13	102	51	143

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	14	76	24	57
disruptive	35	221	108	211
missense	29	197	98	152

PlasmoDB Total SNPs: 161

Non-coding: 91 | Synonymous: 37 | Nonsynonymous: 33 | Stop Codon: 0

Protein Information

Protein Length: 813 | Molecular Weight (kDa): 97.345

UniProt ID(s): Q8IKE8

PDB ID(s): None

Isoelectric Point: 7.09

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR013087	Zinc finger C2H2-type
InterPro	IPR025239	Domain of unknown function DUF4187
InterPro	IPR039727	SERRATE/Ars2
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108