Genome location: Pf3D7_14_v3:2,834,924..2,836,465(-)
Genome classification: Core
Product Description: translation initiation factor IF-1
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Component | GO:0005829 | cytosol |
| Function | GO:0043022 | ribosome binding |
| Function | GO:0003743 | translation initiation factor activity |
| Process | GO:0006413 | translational initiation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.05 | 0.98 |
| Trophozoite | expressed | 0.26 | 0.84 |
| Schizont | expressed | 0.18 | 0.87 |
| Gametocyte | not expressed | 0.26 | 0.84 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1469000
Resistome Missense Mutations: Y25F
Resistome Compounds with Missense Mutations: AN13956
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.139 | MFS: -3.215 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1332200)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKE7
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 9 | 5 | 12 |
| disruptive | 2 | 21 | 11 | 33 |
| missense | 2 | 19 | 10 | 29 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 20 | 11 | 11 |
| disruptive | 10 | 45 | 39 | 51 |
| missense | 5 | 31 | 34 | 34 |
PlasmoDB Total SNPs: 43
Non-coding: 35 | Synonymous: 1 | Nonsynonymous: 7 | Stop Codon: 0
Protein Length: 182 | Molecular Weight (kDa): 21.898
UniProt ID(s): Q8IKE7
PDB ID(s): None
Isoelectric Point: 10.67
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004368 | Translation initiation factor IF-1 |
| InterPro | IPR006196 | RNA-binding domain, S1, IF1 type |
| InterPro | IPR012340 | Nucleic acid-binding, OB-fold |
| PFam | PF01176 | RNA-binding domain, S1, IF1 type |
| Superfamily | SSF50249 | Nucleic acid-binding, OB-fold |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 25689481 | Targeting and function of proteins mediating translation initiation in organellesof Plasmodium falciparum. | Haider A, Allen SM, ..., Habib S | 10.1111/mmi.12972 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |