PF3D7_1469100

Genome location: Pf3D7_14_v3:2,837,195..2,838,651(+)

Genome classification: Core

Function and Localization

Product Description: Golgi SNAP receptor complex member 1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005797	Golgi medial cisterna
Component	GO:0000139	Golgi membrane
Component	GO:0031201	SNARE complex
Component	GO:0005801	cis-Golgi network
Function	GO:0005484	SNAP receptor activity
Process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport
Process	GO:0048209	regulation of vesicle targeting, to, from or within Golgi
Process	GO:0006906	vesicle fusion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.31	0.85
Trophozoite	possibly expressed	0.48	0.72
Schizont	not expressed	0.15	0.90
Gametocyte	possibly expressed	0.62	0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1469100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.128 | MFS: -3.054 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKE6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533148

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	14	4	16
disruptive	3	27	21	55
missense	2	24	19	52

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	24	16	19
disruptive	10	81	48	97
missense	4	69	43	58

PlasmoDB Total SNPs: 83

Non-coding: 76 | Synonymous: 2 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 260 | Molecular Weight (kDa): 31.373

UniProt ID(s): Q8IKE6

PDB ID(s): None

Isoelectric Point: 9.92

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR023601	Golgi SNAP receptor complex, subunit 1
PFam	N/A	N/A
Superfamily	N/A	N/A