PF3D7_1469500

Genome location: Pf3D7_14_v3:2,846,840..2,849,422(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.12	0.94
Trophozoite	not expressed	0.13	0.92
Schizont	not expressed	0.02	0.99
Gametocyte	not expressed	0.09	0.95

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1469500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.135 | MFS: -3.022 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1332600)

Relative Growth Rate: 0.09 ± 0.12
Confidence: 5.68

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKE2

"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=1.48) with 6JWQ (Global RMSD=28.89)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533396

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	37	31	41
disruptive	27	127	97	179
missense	19	122	84	165

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	11	83	31	54
disruptive	55	314	124	206
missense	35	273	105	162

PlasmoDB Total SNPs: 98

Non-coding: 15 | Synonymous: 27 | Nonsynonymous: 56 | Stop Codon: 0

Protein Information

Protein Length: 687 | Molecular Weight (kDa): 81.947

UniProt ID(s): Q8IKE2

PDB ID(s): None

Isoelectric Point: 9.29

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A