Genome location: Pf3D7_14_v3:2,851,140..2,863,232(+)
Genome classification: Core
Product Description: acetyl-CoA carboxylase
SignalP Peptide: MINFFLSLLLFVLFFENLVVS
# Transmembrane Domains: 0
EC Numbers: 6.3.4.14 (Biotin carboxylase);6.4.1.2 (Acetyl-CoA carboxylase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0009317 | acetyl-CoA carboxylase complex |
| Component | GO:0020011 | apicoplast |
| Component | GO:0009343 | biotin carboxylase complex |
| Function | GO:0003989 | acetyl-CoA carboxylase activity |
| Function | GO:0009374 | biotin binding |
| Function | GO:0004075 | biotin carboxylase activity |
| Process | GO:0006633 | fatty acid biosynthetic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.08 | 0.96 |
| Trophozoite | not expressed | 0.29 | 0.84 |
| Schizont | possibly expressed | 0.20 | 0.88 |
| Gametocyte | expressed | 0.95 | 0.53 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1469600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.092 | #Insertions: 5
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1332800)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: N/A
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q5SWU9 | Acetyl-CoA carboxylase 1 | Mus musculus | OMA, OrthoDB | CHEMBL3110076CHEMBL4528475CHEMBL4060253 |
| Q13085 | Acetyl-CoA carboxylase 1 | Homo sapiens | OMA, OrthoDB | US8470841, 59US8470841, 35US8993586, 1US8993586, 2... |
| A0A0D1DYD5 | Acetyl-CoA carboxylase | OMA, OrthoDB, OrthoMCL | US11375716, Formula Ia-iMLS001204131US11375716, Formula Ia-iiiUS11375716, Formula Ia-iv... | |
| E9Q4Z2 | Acetyl-CoA carboxylase 2 | Mus musculus | OrthoDB | CHEMBL3110076CHEMBL4060253 |
| O00763 | Acetyl-CoA carboxylase 2 | Homo sapiens | OrthoDB | US8530460, 4.11US8962641, 8.1US8470841, 2US8470841, 4... |
| P11497 | Acetyl-CoA carboxylase 1 | Rattus norvegicus | OrthoDB | US8470841, 35CHEMBL3359265CHEMBL2419601CHEMBL1091588... |
| Q3V4E6 | Acetyl-CoA carboxylase | OrthoMCL BLAST | US11375716, Formula Ia-iMLS001204131US11375716, Formula Ia-iiiUS11375716, Formula Ia-iv... |
Ortholog Group (OrthoMCL): OG6_101052
Most Similar Human Ortholog: Not available
TM-align score: 0.00 | RMSD: 0.00
Seq Identity: 0.00 | Length: / 3367
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000076555 | acetyl-CoA carboxylase beta |
| ENSG00000275176 | acetyl-CoA carboxylase alpha |
| ENSG00000278540 | acetyl-CoA carboxylase alpha |
Protein Length: 3367 | Molecular Weight (kDa): 394.881
PDB ID(s): None
Isoelectric Point: 7.74
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000089 | Biotin/lipoyl attachment |
| InterPro | IPR005479 | Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain |
| InterPro | IPR005481 | Biotin carboxylase-like, N-terminal domain |
| InterPro | IPR005482 | Biotin carboxylase, C-terminal |
| InterPro | IPR011053 | Single hybrid motif |
| InterPro | IPR011054 | Rudiment single hybrid motif |
| InterPro | IPR016185 | Pre-ATP-grasp domain superfamily |
| InterPro | IPR029045 | ClpP/crotonase-like domain superfamily |
| InterPro | IPR034733 | Acetyl-CoA carboxylase |
| PFam | PF00289 | Biotin carboxylase-like, N-terminal domain |
| PFam | PF00364 | Biotin/lipoyl attachment |
| PFam | PF01039 | Acetyl-CoA carboxylase |
| PFam | PF02785 | Biotin carboxylase, C-terminal |
| PFam | PF02786 | Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain |
| Superfamily | SSF51230 | Single hybrid motif |
| Superfamily | SSF51246 | Rudiment single hybrid motif |
| Superfamily | SSF52096 | ClpP/crotonase-like domain superfamily |
| Superfamily | SSF52440 | Pre-ATP-grasp domain superfamily |
| Superfamily | SSF56059 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 34 | 208 | 99 | 220 |
| disruptive | 156 | 524 | 253 | 647 |
| missense | 125 | 478 | 233 | 566 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 66 | 384 | 156 | 223 |
| disruptive | 271 | 1057 | 440 | 894 |
| missense | 209 | 918 | 364 | 648 |
PlasmoDB Total SNPs: 502
Non-coding: 140 | Synonymous: 161 | Nonsynonymous: 201 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 24583112 | Apicoplast acetyl Co-A carboxylase of the human malaria parasite is not targetedby cyclohexanedione herbicides. | Goodman CD, Mollard V, ..., McFadden GI | 10.1016/j.ijpara.2014.01.007 |
| 29483266 | Host biotin is required for liver stage development in malaria parasites. | Dellibovi-Ragheb TA, Jhun H, ..., Prigge ST | 10.1073/pnas.1800717115 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |