Genome location: Pf3D7_14_v3:2,864,823..2,866,245(-)
Genome classification: Core
Product Description: mediator of RNA polymerase II transcription subunit 22, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0016592 | mediator complex |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.06 | 0.97 |
| Trophozoite | expressed | 0.48 | 0.71 |
| Schizont | expressed | 0.45 | 0.74 |
| Gametocyte | expressed | 0.89 | 0.54 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1469800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.169 | MFS: -2.835 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKD9
"Best" AlphaFill ligand hit: A2P (adenosine-2'-5'-diphosphate, Local RMSD=0.19) with 3JQQ (Global RMSD=23.96)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 16 | 8 | 23 |
| disruptive | 13 | 36 | 20 | 47 |
| missense | 12 | 36 | 19 | 43 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 30 | 17 | 17 |
| disruptive | 21 | 77 | 49 | 83 |
| missense | 18 | 68 | 41 | 52 |
PlasmoDB Total SNPs: 92
Non-coding: 75 | Synonymous: 10 | Nonsynonymous: 7 | Stop Codon: 0
Protein Length: 215 | Molecular Weight (kDa): 25.168
UniProt ID(s): Q8IKD9
PDB ID(s): None
Isoelectric Point: 5.7
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 35557691 | Mediator Complex of the Malaria Parasite Plasmodium falciparum Associates withEvolutionarily Novel Subunits. | Iyer UB, Park JE, ..., Featherstone M | 10.1021/acsomega.2c00368 |