Genome location: Pf3D7_14_v3:2,866,150..2,868,183(+)
Genome classification: Core
Product Description: protein MGET
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB): None
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | not expressed | 0.03 | 0.98 |
| Trophozoite | not expressed | 0.16 | 0.90 |
| Schizont | not expressed | 0.37 | 0.78 |
| Gametocyte | expressed | 1.62 | 0.38 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1469900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.705 | MFS: -2.41 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKD8
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_105134
Most Similar Human Ortholog: B8ZZA5
TM-align score: 0.66 | RMSD: 3.22
Seq Identity: 0.17 | Length: 194 / 398
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000135968 | GRIP and coiled-coil domain containing 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 21 | 7 | 27 |
| disruptive | 13 | 73 | 27 | 74 |
| missense | 13 | 71 | 27 | 69 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 38 | 20 | 47 |
| disruptive | 33 | 154 | 67 | 174 |
| missense | 31 | 127 | 54 | 108 |
PlasmoDB Total SNPs: 141
Non-coding: 90 | Synonymous: 32 | Nonsynonymous: 19 | Stop Codon: 0
Protein Length: 398 | Molecular Weight (kDa): 46.834
UniProt ID(s): Q8IKD8
PDB ID(s): None
Isoelectric Point: 9.85
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |