Genome location: Pf3D7_14_v3:2,868,291..2,869,525(-)
Genome classification: Core
Product Description: autophagy-related protein 12, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0034274 | Atg12-Atg5-Atg16 complex |
| Component | GO:0034045 | phagophore assembly site membrane |
| Function | GO:0005515 | protein binding |
| Process | GO:0006501 | C-terminal protein lipidation |
| Process | GO:0000045 | autophagosome assembly |
| Process | GO:0000422 | autophagy of mitochondrion |
| Process | GO:0044804 | autophagy of nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.05 | 0.97 |
| Trophozoite | no data | 0.42 | 0.74 |
| Schizont | no data | 0.09 | 0.94 |
| Gametocyte | no data | 0.19 | 0.88 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1470000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.319 | MFS: -3.735 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6S3K2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103577
Most Similar Human Ortholog: O94817
TM-align score: 0.70 | RMSD: 1.52
Seq Identity: 0.26 | Length: 86 / 112
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000145782 | autophagy related 12 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 6 | 1 | 10 |
| disruptive | 1 | 4 | 5 | 11 |
| missense | 1 | 4 | 5 | 11 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 10 | 3 | 9 |
| disruptive | 3 | 18 | 10 | 27 |
| missense | 1 | 14 | 8 | 22 |
PlasmoDB Total SNPs: 81
Non-coding: 71 | Synonymous: 9 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 112 | Molecular Weight (kDa): 13.334
UniProt ID(s): C6S3K2
PDB ID(s): None
Isoelectric Point: 9.6
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007242 | Ubiquitin-like protein Atg12 |
| InterPro | IPR029071 | Ubiquitin-like domain superfamily |
| PFam | PF04110 | Ubiquitin-like protein Atg12 |
| Superfamily | SSF54236 | Ubiquitin-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 30911187 | Evolution from covalent conjugation to non-covalent interaction in theubiquitin-like ATG12 system. | Pang Y, Yamamoto H, ..., Mizushima N | 10.1038/s41594-019-0204-3 |