PF3D7_1470100

Genome location: Pf3D7_14_v3:2,869,766..2,878,218(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0005096	GTPase activator activity
Function	GO:0048487	beta-tubulin binding
Process	GO:0000226	microtubule cytoskeleton organization
Process	GO:0006457	protein folding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.15	0.93
Trophozoite	possibly expressed	0.79	0.57
Schizont	not expressed	0.21	0.87
Gametocyte	not expressed	0.55	0.71

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1470100

Resistome Missense Mutations: T1521M, L2246S

Resistome Compounds with Missense Mutations: GNF-Pf-3600, MMV009063

Resistome # Samples with Disruptive Mutations: 2 (2 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.124 | MFS: -3.176 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKD7

"Best" AlphaFill ligand hit: CXS (3-cyclohexyl-1-propylsulfonic acid, Local RMSD=1.66) with 8DOC (Global RMSD=14.99)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532309

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	23	135	81	183
disruptive	85	379	204	479
missense	69	353	191	440

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	43	283	129	190
disruptive	155	817	333	674
missense	117	710	280	489

PlasmoDB Total SNPs: 293

Non-coding: 116 | Synonymous: 99 | Nonsynonymous: 78 | Stop Codon: 0

Protein Information

Protein Length: 2454 | Molecular Weight (kDa): 295.114

UniProt ID(s): Q8IKD7

PDB ID(s): None

Isoelectric Point: 8.04

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR016024	Armadillo-type fold
InterPro	IPR033162	Tubulin-folding cofactor D
PFam	N/A	N/A
Superfamily	SSF48371	Armadillo-type fold

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
12368868	Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14.	Gardner MJ, Shallom SJ, ..., Fraser CM	10.1038/nature01094