PF3D7_1470200

Genome location: Pf3D7_14_v3:2,876,783..2,879,022(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.61	0.72
Trophozoite	not expressed	0.29	0.84
Schizont	not expressed	0.07	0.96
Gametocyte	not expressed	0.72	0.60

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1470200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.521 | MFS: -2.726 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKD6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533167

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	19	8	13
disruptive	3	11	7	30
missense	1	9	4	25

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	28	8	15
disruptive	4	35	25	59
missense	2	27	16	36

PlasmoDB Total SNPs: 50

Non-coding: 43 | Synonymous: 7 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 181 | Molecular Weight (kDa): 21.948

UniProt ID(s): Q8IKD6

PDB ID(s): None

Isoelectric Point: 4.35

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A