Genome location: Pf3D7_14_v3:2,879,948..2,881,746(-)
Genome classification: Core
Product Description: mitochondrial pyruvate carrier protein 2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.01 | 1.00 |
| Trophozoite | expressed | 0.09 | 0.94 |
| Schizont | expressed | 0.10 | 0.94 |
| Gametocyte | expressed | 0.08 | 0.95 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1470400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.331 | MFS: -2.167 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKD4
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| O95563 | Mitochondrial pyruvate carrier 2 | OMA, OrthoDB | US9562012, mitoglitazoneCHEMBL4291468 |
Ortholog Group (OrthoMCL): OG6_101975
Most Similar Human Ortholog: O95563
TM-align score: 0.77 | RMSD: 2.91
Seq Identity: 0.26 | Length: 123 / 129
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000143158 | mitochondrial pyruvate carrier 2 |
Protein Length: 129 | Molecular Weight (kDa): 15.255
UniProt ID(s): Q8IKD4
PDB ID(s): None
Isoelectric Point: 10.3
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR005336 | Mitochondrial pyruvate carrier |
| PFam | PF03650 | Mitochondrial pyruvate carrier |
| Superfamily | N/A | N/A |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 103
Non-coding: 89 | Synonymous: 12 | Nonsynonymous: 2 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 25032958 | BCKDH: the missing link in apicomplexan mitochondrial metabolism is required forfull virulence of Toxoplasma gondii and Plasmodium berghei. | Oppenheim RD, Creek DJ, ..., Soldati-Favre D | 10.1371/journal.ppat.1004263 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 37238591 | NMR and Patch-Clamp Characterization of Yeast Mitochondrial Pyruvate CarrierComplexes | Wang Z, Ding W, ..., Li Y | 10.3390/biom13050719 |
| 36920199 | The Mitochondrial Pyruvate Carrier Coupling Glycolysis and the Tricarboxylic AcidCycle Is Required for the Asexual Reproduction of Toxoplasma gondii | Lyu C, Chen Y, ..., Shen B | 10.1128/spectrum.05043-22 |
| 36295675 | Experimental Investigations on the Structure of Yeast Mitochondrial PyruvateCarriers | Li L, Wen M, ..., OuYang B | 10.3390/membranes12100916 |