Genome location: Pf3D7_14_v3:2,886,759..2,889,065(-)
Genome classification: Core
Product Description: RAP protein RAP21
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Component | GO:0005634 | nucleus |
| Function | GO:0097177 | mitochondrial ribosome binding |
| Function | GO:0019843 | rRNA binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | possibly expressed | 0.22 | 0.89 |
| Trophozoite | expressed | 0.52 | 0.70 |
| Schizont | expressed | 0.06 | 0.96 |
| Gametocyte | not expressed | 0.61 | 0.65 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1470600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.23 | MFS: -2.603 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1333800)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A144A2U7
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 27 | 15 | 28 |
| disruptive | 24 | 101 | 51 | 97 |
| missense | 16 | 88 | 48 | 85 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 55 | 24 | 34 |
| disruptive | 43 | 179 | 78 | 145 |
| missense | 26 | 159 | 66 | 113 |
PlasmoDB Total SNPs: 165
Non-coding: 110 | Synonymous: 32 | Nonsynonymous: 23 | Stop Codon: 0
Protein Length: 533 | Molecular Weight (kDa): 64.17
UniProt ID(s): A0A144A2U7
PDB ID(s): None
Isoelectric Point: 5.68
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR013584 | RAP domain |
| PFam | PF08373 | RAP domain |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 35277503 | Functional genomics of RAP proteins and their role in mitoribosome regulation inPlasmodium falciparum. | Hollin T, Abel S, ..., Le Roch KG | 10.1038/s41467-022-28981-7 |