About Gene List

PF3D7_1470800

Genome location: Pf3D7_14_v3:2,892,097..2,896,218(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.15 0.93
Trophozoite expressed 1.17 0.44
Schizont expressed 0.67 0.69
Gametocyte expressed 1.08 0.44

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1470800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.121 | MFS: -3.066 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1334000)

  • Relative Growth Rate: 0.10 ± 0.32
  • Confidence: 3.68

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKD0

"Best" AlphaFill ligand hit: UMP (2'-deoxyuridine 5'-monophosphate, Local RMSD=0.58) with 7S01 (Global RMSD=36.69)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532696

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 11 52 36 68
disruptive 17 82 64 153
missense 15 77 58 133

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 16 118 53 84
disruptive 49 195 120 242
missense 28 166 106 193

PlasmoDB Total SNPs: 167

Non-coding: 110 | Synonymous: 36 | Nonsynonymous: 21 | Stop Codon: 0

Protein Information

Protein Length: 1095 | Molecular Weight (kDa): 131.075

UniProt ID(s): Q8IKD0

PDB ID(s): None

Isoelectric Point: 9.26

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
19400777 Cooperativity between Plasmodium falciparum adhesive proteins for invasion intoerythrocytes. DeSimone TM, Jennings CV, ..., Duraisingh MT 10.1111/j.1365-2958.2009.06667.x
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895