Product Description: proteasome subunit beta type-2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.4.25.1 (Proteasome endopeptidase complex)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:1903561 | extracellular vesicle |
| Component | GO:0005634 | nucleus |
| Component | GO:0005839 | proteasome core complex |
| Function | GO:0004175 | endopeptidase activity |
| Process | GO:0010498 | proteasomal protein catabolic process |
| Process | GO:0010499 | proteasomal ubiquitin-independent protein catabolic process |
| Process | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| Process | GO:0006511 | ubiquitin-dependent protein catabolic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.10 | 0.95 |
| Trophozoite | expressed | 0.42 | 0.74 |
| Schizont | expressed | 0.20 | 0.86 |
| Gametocyte | expressed | 0.19 | 0.88 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1470900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -2.935 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1334100)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKC9
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.4.25.1 | proteasome endopeptidase complex | ATPSDSPSIEDTANH4+EGTATLCKALLNNMDANLVSPI 1PA28... |
Orthology to BindingDB Entries:
Ortholog Group (OrthoMCL): OG6_102061
Most Similar Human Ortholog: P49721
TM-align score: 0.96 | RMSD: 1.07
Seq Identity: 0.38 | Length: 194 / 195
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000126067 | proteasome 20S subunit beta 2 |
Protein Length: 195 | Molecular Weight (kDa): 22.862
UniProt ID(s): Q8IKC9
PDB ID(s): 5FMG, 6MUV, 6MUW, 6MUX, 7LXT, 7LXU
Isoelectric Point: 7.26
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001353 | Proteasome, subunit alpha/beta |
| InterPro | IPR016050 | Proteasome beta-type subunit, conserved site |
| InterPro | IPR029055 | Nucleophile aminohydrolases, N-terminal |
| InterPro | IPR035206 | Proteasome subunit beta 2 |
| PFam | PF00227 | Proteasome, subunit alpha/beta |
| Superfamily | SSF56235 | Nucleophile aminohydrolases, N-terminal |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 14 | 5 | 14 |
| disruptive | 0 | 8 | 8 | 18 |
| missense | 0 | 8 | 8 | 18 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 27 | 12 | 15 |
| disruptive | 3 | 29 | 21 | 47 |
| missense | 1 | 24 | 19 | 40 |
PlasmoDB Total SNPs: 151
Non-coding: 143 | Synonymous: 7 | Nonsynonymous: 1 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 33608523 | 20S proteasomes secreted by the malaria parasite promote its growth. | Dekel E, Yaffe D, ..., Regev-Rudzki N | 10.1038/s41467-021-21344-8 |