Genome location: Pf3D7_14_v3:2,911,299..2,915,962(+)
Genome classification: Core
Product Description: inorganic anion exchanger, inorganic anion antiporter
SignalP Peptide: N/A
# Transmembrane Domains: 11
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005887 | integral component of plasma membrane |
| Component | GO:0005886 | plasma membrane |
| Process | GO:0009410 | response to xenobiotic stimulus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.06 | 0.97 |
| Trophozoite | expressed | 0.21 | 0.86 |
| Schizont | expressed | 0.13 | 0.91 |
| Gametocyte | expressed | 0.16 | 0.90 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1471200
Resistome Missense Mutations: D520Y, I596M, K615N
Resistome Compounds with Missense Mutations: MMV668399
Resistome # Samples with Disruptive Mutations: 6 (6 missense, 3 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.247 | MFS: -2.611 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKC7
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 50 | 17 | 41 |
| disruptive | 3 | 12 | 7 | 31 |
| missense | 2 | 12 | 7 | 25 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 16 | 88 | 21 | 46 |
| disruptive | 7 | 41 | 30 | 112 |
| missense | 4 | 28 | 22 | 82 |
PlasmoDB Total SNPs: 342
Non-coding: 306 | Synonymous: 33 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 664 | Molecular Weight (kDa): 75.468
UniProt ID(s): Q8IKC7
PDB ID(s): None
Isoelectric Point: 8.49
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR011547 | SLC26A/SulP transporter domain |
| PFam | PF00916 | SLC26A/SulP transporter domain |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 11152613 | Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. | Krogh A, Larsson B, von Heijne G, Sonnhammer EL | 10.1006/jmbi.2000.4315 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 17870052 | Localisation of a candidate anion transporter to the surface of the malariaparasite. | Henry RI, Martin RE, Howitt SM, Kirk K | 10.1016/j.bbrc.2007.08.116 |
| 29326268 | Mapping the malaria parasite druggable genome by using in vitro evolution andchemogenomics. | Cowell AN, Istvan ES, ..., Winzeler EA | 10.1126/science.aan4472 |