PF3D7_1471300

Genome location: Pf3D7_14_v3:2,915,387..2,918,183(-)

Genome classification: Core

Function and Localization

Product Description: RAP protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.09	0.95
Trophozoite	expressed	0.66	0.63
Schizont	possibly expressed	0.19	0.87
Gametocyte	not expressed	0.38	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1471300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.132 | MFS: -3.107 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKC6

"Best" AlphaFill ligand hit: CLQ (n4-(7-chloro-quinolin-4-yl)-n1,n1-diethyl-pentane-1,4-diamine, Local RMSD=6.89) with 7DI7 (Global RMSD=20.30)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533762

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	39	21	34
disruptive	26	105	70	134
missense	19	89	63	109

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	18	62	32	44
disruptive	45	227	97	191
missense	31	188	75	133

PlasmoDB Total SNPs: 159

Non-coding: 86 | Synonymous: 21 | Nonsynonymous: 45 | Stop Codon: 7

Protein Information

Protein Length: 581 | Molecular Weight (kDa): 70.722

UniProt ID(s): Q8IKC6

PDB ID(s): None

Isoelectric Point: 9.57

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR013584	RAP domain
PFam	N/A	N/A
Superfamily	N/A	N/A