PF3D7_1471500 (TMEM43)

Genome location: Pf3D7_14_v3:2,922,351..2,924,557(-)

Genome classification: Core

Function and Localization

Product Description: transmembrane protein 43, putative

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005639	integral component of nuclear inner membrane
Component	GO:0016020	membrane
Process	GO:0071763	nuclear membrane organization

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.03	0.99
Trophozoite	expressed	0.10	0.94
Schizont	expressed	0.13	0.91
Gametocyte	expressed	0.54	0.70

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1471500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.873 | MFS: -2.105 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1334700)

Relative Growth Rate: 0.96 ± 0.21
Confidence: 4.54

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_1339400)

Modification: Disrupted | RMgm-4791

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKC4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_145838

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	25	17	27
disruptive	5	26	8	42
missense	5	25	7	37

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	49	20	36
disruptive	15	54	38	79
missense	13	43	31	61

PlasmoDB Total SNPs: 148

Non-coding: 128 | Synonymous: 10 | Nonsynonymous: 7 | Stop Codon: 3

Protein Information

Protein Length: 443 | Molecular Weight (kDa): 51.508

UniProt ID(s): Q8IKC4

PDB ID(s): None

Isoelectric Point: 8.62

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR012430	Transmembrane protein 43 family
PFam	PF07787	Transmembrane protein 43 family
Superfamily	N/A	N/A