Genome location: Pf3D7_14_v3:2,925,721..2,929,673(+)
Genome classification: Core
Product Description: apical polar ring protein APR2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020007 | apical complex |
| Component | GO:0020031 | polar ring of apical complex |
| Function | GO:0008017 | microtubule binding |
| Process | GO:0071976 | cell gliding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.02 | 0.99 |
| Trophozoite | not expressed | 0.03 | 0.98 |
| Schizont | not expressed | 0.02 | 0.99 |
| Gametocyte | expressed | 1.28 | 0.54 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1471600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.434 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not tested (Pb ortholog: PY17X_1339500)
Modification: Tagged | RMgm-5291
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKC3
"Best" AlphaFill ligand hit: PHB (p-hydroxybenzoic acid, Local RMSD=21.00) with 6KCK (Global RMSD=35.02)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 62 | 44 | 100 |
| disruptive | 65 | 225 | 111 | 281 |
| missense | 39 | 199 | 104 | 254 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 16 | 121 | 70 | 101 |
| disruptive | 108 | 418 | 203 | 354 |
| missense | 64 | 373 | 173 | 269 |
PlasmoDB Total SNPs: 164
Non-coding: 43 | Synonymous: 43 | Nonsynonymous: 78 | Stop Codon: 0
Protein Length: 1179 | Molecular Weight (kDa): 136.242
UniProt ID(s): Q8IKC3
PDB ID(s): None
Isoelectric Point: 9.77
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 33705380 | Molecular characterization of the conoid complex in Toxoplasma reveals itsconservation in all apicomplexans, including Plasmodium species. | Koreny L, Zeeshan M, ..., Waller RF | 10.1371/journal.pbio.3001081 |
| 36463257 | Apical anchorage and stabilization of subpellicular microtubules by apical polarring ensures Plasmodium ookinete infection in mosquito | Qian P, Wang X, ..., Yuan J | 10.1038/s41467-022-35270-w |