PF3D7_1471700

Genome location: Pf3D7_14_v3:2,929,823..2,931,547(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	not expressed	0.01	0.99
Schizont	not expressed	0.01	0.99
Gametocyte	expressed	0.37	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1471700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.994 | MFS: -2.006 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKC2

"Best" AlphaFill ligand hit: FAD (flavin-adenine dinucleotide, Local RMSD=0.74) with 8C3M (Global RMSD=23.29)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533586

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	27	18	40
disruptive	26	95	54	123
missense	24	92	52	118

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	50	36	51
disruptive	38	210	83	154
missense	32	200	79	133

PlasmoDB Total SNPs: 47

Non-coding: 0 | Synonymous: 22 | Nonsynonymous: 25 | Stop Codon: 0

Protein Information

Protein Length: 574 | Molecular Weight (kDa): 67.546

UniProt ID(s): Q8IKC2

PDB ID(s): None

Isoelectric Point: 9.21

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A