PF3D7_1471800

Genome location: Pf3D7_14_v3:2,931,759..2,932,950(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	0.99
Trophozoite	not expressed	0.04	0.98
Schizont	not expressed	0.00	1.00
Gametocyte	expressed	0.49	0.75

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1471800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 1 | MFS: -1.182 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKC1

"Best" AlphaFill ligand hit: UMP (2'-deoxyuridine 5'-monophosphate, Local RMSD=0.23) with 3UM6 (Global RMSD=25.48)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532353

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	11	6	13
disruptive	12	35	17	50
missense	12	34	16	46

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	19	14	26
disruptive	20	69	39	78
missense	17	63	34	56

PlasmoDB Total SNPs: 49

Non-coding: 28 | Synonymous: 12 | Nonsynonymous: 9 | Stop Codon: 0

Protein Information

Protein Length: 254 | Molecular Weight (kDa): 30.992

UniProt ID(s): Q8IKC1

PDB ID(s): None

Isoelectric Point: 7.85

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A