PF3D7_1471900

Genome location: Pf3D7_14_v3:2,932,831..2,939,893(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.33	0.85
Trophozoite	expressed	0.60	0.68
Schizont	not expressed	0.10	0.94
Gametocyte	not expressed	0.94	0.55

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1471900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.78 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A5C9

"Best" AlphaFill ligand hit: PH2 (2-amino-6-hydroxymethyl-7,8-dihydro-3h-pteridin-4-one, Local RMSD=0.09) with 6JWR (Global RMSD=13.06)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532336

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	18	116	66	135
disruptive	76	414	244	496
missense	54	371	226	442

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	32	215	95	153
disruptive	175	833	332	614
missense	108	724	300	479

PlasmoDB Total SNPs: 268

Non-coding: 31 | Synonymous: 100 | Nonsynonymous: 137 | Stop Codon: 0

Protein Information

Protein Length: 2128 | Molecular Weight (kDa): 256.342

UniProt ID(s): A0A144A5C9

PDB ID(s): None

Isoelectric Point: 9.73

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR038765	Papain-like cysteine peptidase superfamily
PFam	N/A	N/A
Superfamily	SSF54001	Papain-like cysteine peptidase superfamily