Genome location: Pf3D7_14_v3:2,941,398..2,945,279(-)
Genome classification: Core
Product Description: protein transport protein YIP1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 5
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Process | GO:0016192 | vesicle-mediated transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.08 | 0.96 |
| Trophozoite | expressed | 0.08 | 0.95 |
| Schizont | expressed | 0.04 | 0.97 |
| Gametocyte | expressed | 0.11 | 0.93 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1472100
Resistome Missense Mutations: S215N
Resistome Compounds with Missense Mutations: MMV007224
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.449 | MFS: -2.274 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1335300)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKB7
"Best" AlphaFill ligand hit: UPG (uridine-5'-diphosphate-glucose, Local RMSD=0.66) with 7UBY (Global RMSD=17.86)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101570
Most Similar Human Ortholog: E5RHH4
TM-align score: 0.65 | RMSD: 1.97
Seq Identity: 0.35 | Length: 124 / 314
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000145817 | Yip1 domain family member 5 |
| ENSG00000177752 | Yip1 domain family member 7 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 1 | 0 | 1 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 1 | 1 | 3 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 264
Non-coding: 248 | Synonymous: 11 | Nonsynonymous: 5 | Stop Codon: 0
Protein Length: 314 | Molecular Weight (kDa): 36.344
UniProt ID(s): Q8IKB7
PDB ID(s): None
Isoelectric Point: 7.74
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006977 | Yip1 domain |
| PFam | PF04893 | Yip1 domain |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 31631203 | A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. | Das D, Krishnan SR, Roy A, Bulusu G | 10.1039/c9mo00124g |
| 34466146 | lncRNA and mRNA sequencing of the left testis in experimental varicocele ratstreated with Morinda officinalis polysaccharide | Zhang L, Zhao X, Wang W | 10.3892/etm.2021.10570 |