Genome location: Pf3D7_14_v3:2,944,069..2,953,562(+)
Genome classification: Core
Product Description: histone deacetylase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 3
EC Numbers: 3.5.1.98 (Histone deacetylase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.79 | 0.34 |
| Trophozoite | expressed | 1.19 | 0.43 |
| Schizont | expressed | 0.94 | 0.51 |
| Gametocyte | expressed | 1.50 | 0.34 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1472200
Resistome Missense Mutations: L667M, N673K, N677K, N679K, N682K, N684K, E2084G
Resistome Compounds with Missense Mutations: AN13762, AN13956, MMV665794
Resistome # Samples with Disruptive Mutations: 8 (8 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.151 | MFS: -2.835 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A144A4T0
"Best" AlphaFill ligand hit: TSN (trichostatin a, Local RMSD=0.04) with 1T64 (Global RMSD=5.51)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.5.1.98 | histone deacetylase | EDTAPAOASAHAFOXPFK228MCP30shRNAsiRNAMS-275LAQ824MC1575MC1568... |
No evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 31 | 127 | 82 | 147 |
| disruptive | 96 | 305 | 141 | 342 |
| missense | 53 | 233 | 119 | 261 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 48 | 254 | 111 | 159 |
| disruptive | 180 | 583 | 279 | 608 |
| missense | 98 | 425 | 206 | 364 |
PlasmoDB Total SNPs: 491
Non-coding: 199 | Synonymous: 193 | Nonsynonymous: 99 | Stop Codon: 0
Protein Length: 2251 | Molecular Weight (kDa): 268.92
UniProt ID(s): A0A144A4T0
PDB ID(s): None
Isoelectric Point: 9.35
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000286 | Histone deacetylase family |
| InterPro | IPR023696 | Ureohydrolase domain superfamily |
| InterPro | IPR023801 | Histone deacetylase domain |
| InterPro | IPR036770 | Ankyrin repeat-containing domain superfamily |
| PFam | PF00850 | Histone deacetylase domain |
| Superfamily | SSF48403 | Ankyrin repeat-containing domain superfamily |
| Superfamily | SSF52768 | Ureohydrolase domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 36993207 | The chromatin factors SET-26 and HCF-1 oppose the histone deacetylase HDA-1 inlongevity and gene regulation in C. elegans | Emerson FJ, Chiu C, ..., Lee SS | 10.1101/2023.03.20.531974 |
| 38334386 | The histone deacetylase Hda1 affects oxidative and osmotic stress response aswell as mycoparasitic activity and secondary metabolite biosynthesis in Trichoderma atroviride | Speckbacher V, Flatschacher D, ..., Zeilinger S | 10.1128/spectrum.03097-23 |
| 37874684 | The Saccharomyces cerevisiae acetyltransferase Gcn5 exerts antagonisticpleiotropic effects on chronological ageing | Li K, Mocciaro G, Griffin JL, Zhang N | 10.18632/aging.205109 |
| 37074817 | Origin of the kinetic HDAC2-selectivity of an HDAC inhibitor | Mishima H, Itoh Y, ..., Okamoto Y | 10.1002/jcc.27111 |