About Gene List

PF3D7_1472300

Genome location: Pf3D7_14_v3:2,954,108..2,957,273(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 7

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0009986 cell surface

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.22 0.88
Trophozoite not expressed 0.26 0.83
Schizont possibly expressed 0.31 0.79
Gametocyte possibly expressed 0.20 0.87

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1472300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.146 | MFS: -3.171 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKB5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_126773

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 8 35 13 34
disruptive 6 31 25 58
missense 3 31 23 44

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 13 59 27 43
disruptive 13 80 47 153
missense 8 64 38 97

PlasmoDB Total SNPs: 223

Non-coding: 193 | Synonymous: 26 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 535 | Molecular Weight (kDa): 64.42

UniProt ID(s): Q8IKB5

PDB ID(s): None

Isoelectric Point: 9.03

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
11152613 Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. Krogh A, Larsson B, von Heijne G, Sonnhammer EL 10.1006/jmbi.2000.4315
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
34956931 Merozoite Proteins Discovered by qRT-PCR-Based Transcriptome Screening ofPlasmodium falciparum. Hou N, Li S, ..., Chen Q https://pubmed.ncbi.nlm.nih.gov/34956931/