About Gene List

PF3D7_1472800

Genome location: Pf3D7_14_v3:2,969,590..2,972,068(-)

Genome classification: Core

Function and Localization

Product Description: HSP20-like chaperone, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.14 0.93
Trophozoite possibly expressed 1.00 0.51
Schizont expressed 0.42 0.76
Gametocyte possibly expressed 1.94 0.21

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1472800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.251 | MFS: -2.677 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKB0

"Best" AlphaFill ligand hit: ADE (adenine, Local RMSD=0.60) with 5JRE (Global RMSD=19.85)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533055

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 22 8 26
disruptive 4 35 37 68
missense 3 34 37 57

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 6 40 11 26
disruptive 11 115 53 100
missense 7 97 47 69

PlasmoDB Total SNPs: 215

Non-coding: 204 | Synonymous: 6 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 363 | Molecular Weight (kDa): 43.493

UniProt ID(s): Q8IKB0

PDB ID(s): None

Isoelectric Point: 6.41

Protein Domain Annotations:

Source Family ID Description
InterPro IPR007052 CS domain
InterPro IPR008978 HSP20-like chaperone
PFam PF04969 CS domain
Superfamily SSF49764 HSP20-like chaperone

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895