About Gene List

PF3D7_1473000

Genome location: Pf3D7_14_v3:2,975,115..2,975,492(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.00 1.00
Trophozoite possibly expressed 0.00 1.00
Schizont possibly expressed 0.00 1.00
Gametocyte not expressed 0.00 1.00

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1473000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.107 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKA8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533585

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 8 5 6
disruptive 9 18 14 26
missense 7 17 12 22

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 3 16 5 10
disruptive 13 38 23 40
missense 9 34 21 31

PlasmoDB Total SNPs: 18

Non-coding: 1 | Synonymous: 5 | Nonsynonymous: 12 | Stop Codon: 0

Protein Information

Protein Length: 125 | Molecular Weight (kDa): 14.706

UniProt ID(s): Q8IKA8

PDB ID(s): None

Isoelectric Point: 4.31

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094