PF3D7_1473100

Genome location: Pf3D7_14_v3:2,975,858..2,978,839(-)

Genome classification: Core

Function and Localization

Product Description: GTPase-activating protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0005096	GTPase activator activity
Process	GO:0090630	activation of GTPase activity
Process	GO:0006886	intracellular protein transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.18	0.91
Trophozoite	expressed	0.44	0.73
Schizont	expressed	0.14	0.91
Gametocyte	expressed	0.43	0.75

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1473100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.121 | MFS: -2.939 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1336300)

Relative Growth Rate: 0.08 ± 0.11
Confidence: 5.82

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKA7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103725

Most Similar Human Ortholog: C9JDR8

TM-align score: 0.60 | RMSD: 2.91

Seq Identity: 0.28 | Length: 132 / 592

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000131374	TBC1 domain family member 5

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	45	29	41
disruptive	13	68	36	100
missense	11	65	34	91

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	13	88	33	40
disruptive	26	163	72	165
missense	18	142	63	122

PlasmoDB Total SNPs: 154

Non-coding: 110 | Synonymous: 24 | Nonsynonymous: 19 | Stop Codon: 1

Protein Information

Protein Length: 592 | Molecular Weight (kDa): 71.566

UniProt ID(s): Q8IKA7

PDB ID(s): None

Isoelectric Point: 7.01

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000195	Rab-GTPase-TBC domain
InterPro	IPR035969	Rab-GTPase-TBC domain superfamily
PFam	PF00566	Rab-GTPase-TBC domain
Superfamily	SSF47923	Rab-GTPase-TBC domain superfamily