Product Description: DnaJ protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.36 | 0.84 |
| Trophozoite | expressed | 0.89 | 0.53 |
| Schizont | expressed | 0.25 | 0.85 |
| Gametocyte | expressed | 0.91 | 0.55 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1473200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.969 | MFS: -1.95 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKA6
"Best" AlphaFill ligand hit: 1PS (3-pyridinium-1-ylpropane-1-sulfonate, Local RMSD=0.09) with 5AYK (Global RMSD=15.79)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102445
Most Similar Human Ortholog: Q8WXX5
TM-align score: 0.41 | RMSD: 4.29
Seq Identity: 0.22 | Length: 136 / 454
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000213551 | DnaJ heat shock protein family (Hsp40) member C9 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 38 | 28 | 41 |
| disruptive | 44 | 108 | 25 | 80 |
| missense | 24 | 70 | 18 | 55 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 15 | 79 | 28 | 43 |
| disruptive | 85 | 132 | 51 | 134 |
| missense | 48 | 86 | 39 | 91 |
PlasmoDB Total SNPs: 237
Non-coding: 176 | Synonymous: 36 | Nonsynonymous: 25 | Stop Codon: 0
Protein Length: 454 | Molecular Weight (kDa): 52.454
UniProt ID(s): Q8IKA6
PDB ID(s): None
Isoelectric Point: 4.92
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001623 | DnaJ domain |
| InterPro | IPR036869 | Chaperone J-domain superfamily |
| InterPro | IPR042977 | Chaperone protein AtJ6-like |
| PFam | PF00226 | DnaJ domain |
| Superfamily | SSF46565 | Chaperone J-domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 31631203 | A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. | Das D, Krishnan SR, Roy A, Bulusu G | 10.1039/c9mo00124g |