PF3D7_1473300

Genome location: Pf3D7_14_v3:2,984,062..2,987,932(+)

Genome classification: Core

Function and Localization

Product Description: CKK domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.99
Trophozoite	not expressed	0.10	0.94
Schizont	possibly expressed	0.06	0.96
Gametocyte	not expressed	0.28	0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1473300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.351 | #Insertions: 4

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1336500)

Relative Growth Rate: 1.00 ± 0.27
Confidence: 4.00

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1336500)

Modification: Disrupted | RMgm-3572

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKA5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533289

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	82	28	73
disruptive	48	194	93	220
missense	27	174	80	204

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	14	138	41	65
disruptive	80	385	138	303
missense	49	332	119	228

PlasmoDB Total SNPs: 195

Non-coding: 109 | Synonymous: 48 | Nonsynonymous: 38 | Stop Codon: 0

Protein Information

Protein Length: 946 | Molecular Weight (kDa): 114.321

UniProt ID(s): Q8IKA5

PDB ID(s): None

Isoelectric Point: 9.43

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR014797	CKK domain
PFam	N/A	N/A
Superfamily	N/A	N/A