PF3D7_1473400

Genome location: Pf3D7_14_v3:2,989,202..2,993,202(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.10	0.95
Trophozoite	not expressed	0.06	0.97
Schizont	expressed	0.61	0.72
Gametocyte	possibly expressed	0.37	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1473400

Resistome Missense Mutations: I638M

Resistome Compounds with Missense Mutations: Suloctidil

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.56 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1336600)

Modification: Disrupted | RMgm-3573

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKA3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533124

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	10	44	26	73
disruptive	35	140	78	186
missense	33	128	74	167

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	16	93	56	67
disruptive	58	308	132	286
missense	51	271	114	214

PlasmoDB Total SNPs: 210

Non-coding: 129 | Synonymous: 47 | Nonsynonymous: 34 | Stop Codon: 0

Protein Information

Protein Length: 881 | Molecular Weight (kDa): 103.984

UniProt ID(s): Q8IKA3

PDB ID(s): None

Isoelectric Point: 7.77

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	SSF69349	N/A